The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

@article{Tinel2004ThePA,
  title={The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress},
  author={Antoine Tinel and Jürg Tschopp},
  journal={Science},
  year={2004},
  volume={304},
  pages={843 - 846}
}
Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in the caspase-9-activating apoptosome complex. [] Key Result We show that activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Because PIDD…

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