The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1


Endothelial cell-cell junctions control efflux of small molecules and leukocyte transendothelial migration (TEM) between blood and tissues. Inhibitors of phosphoinositide 3-kinases (PI3Ks) increase endothelial barrier function, but the roles of different PI3K isoforms have not been addressed. In this study, we determine the contribution of each of the four… (More)
DOI: 10.1083/jcb.200907135


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