The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis

@article{Bar2005ThePI,
  title={The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis},
  author={Jair Bar and N Lukaschuk and Amir Zalcenstein and Sylvia Wilder and Rony Seger and Moshe Oren},
  journal={Cell Death and Differentiation},
  year={2005},
  volume={12},
  pages={1578-1587}
}
The p53 tumor suppressor plays a key role in the natural protection against cancer. Activation of p53 by DNA-damaging agents can contribute to successful elimination of cancer cells via chemotherapy-induced apoptosis. The phosphatidylinositol-3 kinase (PI3K) pathway, triggered in normal cells upon exposure to growth factors, regulates a cascade of proliferation and survival signals. The PI3K pathway is abnormally active in many cancers, thus making it an attractive target for inactivation in an… CONTINUE READING

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Decision making by p53: life, death and cancer

Cell Death and Differentiation • 2003

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