The PI3K, metabolic, and autophagy networks: interactive partners in cellular health and disease.

@article{Shanware2013ThePM,
  title={The PI3K, metabolic, and autophagy networks: interactive partners in cellular health and disease.},
  author={Naval P. Shanware and Kevin R. Bray and Robert T. Abraham},
  journal={Annual review of pharmacology and toxicology},
  year={2013},
  volume={53},
  pages={
          89-106
        }
}
A fundamental imperative for mammalian cells is to coordinate cell metabolism and growth with environmentally induced stress. This review focuses on three highly integrated networks-the phosphoinositide 3-kinase (PI3K) signaling cascade, intermediate metabolism, and autophagy-that work together to maintain cellular homeostasis under basal conditions and to drive cell-mass accumulation and cell cycle progression in the presence of appropriate mitogenic stimuli. Dysfunction within any one of… CONTINUE READING
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