The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad.

@article{Shimamura2003ThePP,
  title={The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad.},
  author={Haruko Shimamura and Yoshio Terada and Tomokazu Okado and Hiroyuki Tanaka and Seiji Inoshita and Sei Sasaki},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 6},
  pages={1427-34}
}
While the serine/threonine protein kinase Akt has attracted attention as a mediator of survival (anti-apoptotic) signal, the regulation and function of the PI3-kinase-Akt pathway in mesangial cells is not well known. To explore the significance of the PI3-kinase-Akt pathway, this study used PI3-kinase inhibitors (Wortmannin and LY294002) and recombinant adenoviruses encoding a dominant-active mutant of Akt (AxCAmyrAkt) and a dominant-negative mutant of Akt (AxCAAkt-AA) in cultured rat mesangial… CONTINUE READING

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