The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells.

Abstract

Many immune pathologies are the result of aberrant regulation of T lymphocytes. A functional proteomics approach utilizing two-dimensional gel electrophoresis coupled with mass spectrometry was employed to identify differentially expressed proteins in response to T cell activation. Two members of the prohibitin family of proteins, Phb1 and Phb2, were… (More)

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@article{Ross2008ThePP, title={The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells.}, author={Jeremy A. Ross and Zsuzsanna S. Nagy and Robert A. Kirken}, journal={The Journal of biological chemistry}, year={2008}, volume={283 8}, pages={4699-713} }