The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.

  title={The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.},
  author={Ryan P Ceddia and DaeKee Lee and Matthew F. Maulis and Bethany A. Carboneau and David W Threadgill and Greg Poffenberger and Ginger A Milne and Kelli Lynn Boyd and Alvin C Powers and Owen P. McGuinness and Maureen Gannon and Richard M Breyer},
  volume={157 1},
Mice carrying a targeted disruption of the prostaglandin E2 (PGE2) E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted PGE2-EP3 signaling on diabetes in a setting of diet-induced obesity. Although no differences in body weight were seen in mice fed the control diet, when fed a HFD, EP3(-/-) mice gained more weight relative to EP3(+/+) mice. Overall, EP3(-/-) mice had increased epididymal fat… CONTINUE READING


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