The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth.

@article{Fels2006ThePM,
  title={The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth.},
  author={Diane R Fels and Constantinos Koumenis},
  journal={Cancer biology & therapy},
  year={2006},
  volume={5 7},
  pages={723-8}
}
Hypoxia is a dynamic feature of the tumor microenvironment that contributes to cancer progression. In order to adapt and overcome hypoxic stress, tumor cells activate survival pathways that attempt to couple metabolic processes to reduced energy availability due to oxygen deprivation. While the hypoxia-inducible factors HIF-1 and HIF-2 are critical to the cellular response to hypoxia, HIF-independent processes are known to contribute to this adaptation. Recent evidence demonstrates that hypoxia… CONTINUE READING
134 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 134 extracted citations

Similar Papers

Loading similar papers…