The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain

@article{Meerschaert2009ThePD,
  title={The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain},
  author={Kris R A Meerschaert and Moe Phyu Tun and Eline Remue and Ariane De Ganck and Ciska Boucherie and Berlinda Vanloo and Gis{\`e}le Degeest and Jo{\"e}l Vandekerckhove and Pascale Zimmermann and Nitin Bhardwaj and Hui Lu and Wonhwa Cho and Jan Gettemans},
  journal={Cellular and Molecular Life Sciences},
  year={2009},
  volume={66},
  pages={3951-3966}
}
Zonula occludens proteins (ZO) are postsynaptic density protein-95 discs large-zonula occludens (PDZ) domain-containing proteins that play a fundamental role in the assembly of tight junctions and establishment of cell polarity. Here, we show that the second PDZ domain of ZO-1 and ZO-2 binds phosphoinositides (PtdInsP) and we identified critical residues involved in the interaction. Furthermore, peptide and PtdInsP binding of ZO PDZ2 domains are mutually exclusive. Although lipid binding does… CONTINUE READING
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