The PDZ-GEF dizzy regulates cell shape of migrating macrophages via Rap1 and integrins in the Drosophila embryo.

@article{Huelsmann2006ThePD,
  title={The PDZ-GEF dizzy regulates cell shape of migrating macrophages via Rap1 and integrins in the Drosophila embryo.},
  author={Sven Huelsmann and Christina Hepper and Daniele Marchese and Christian Kn{\"o}ll and Rolf Reuter},
  journal={Development},
  year={2006},
  volume={133 15},
  pages={2915-24}
}
In Drosophila embryos, macrophages originate from the cephalic mesoderm and perform a complex migration throughout the entire embryo. The molecular mechanisms regulating this cell migration remain largely unknown. We identified the Drosophila PDZ G-nucleotide exchange factor (PDZ-GEF) Dizzy as a component essential for normal macrophage migration. In mutants lacking Dizzy, macrophages have smaller cellular protrusions, and their migration is slowed down significantly. This phenotype appears to… CONTINUE READING

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