The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter.

Abstract

Keratin 19 is a member of the cytokeratin family that is critical for maintenance of cellular architecture and organization, especially of epithelia. The pancreas has three distinct cell types, ductal, acinar, and islet, each with different functions. Embryologically, the pancreatic and duodenal homeobox 1 (PDX1) homeodomain protein is critical for the… (More)

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@article{Deramaudt2006ThePH, title={The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter.}, author={Th{\'e}r{\`e}se B. Deramaudt and Mira M. Sachdeva and Melanie P. Wescott and Yuting Chen and Doris A. Stoffers and Anil K Rustgi}, journal={The Journal of biological chemistry}, year={2006}, volume={281 50}, pages={38385-95} }