The PDGF/PDGFR pathway as a drug target.

Abstract

Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration, primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed in a wide array of pathological conditions, such as cancer, fibrosis, neurological conditions and atherosclerosis. Reported abnormalities of the PDGF pathway include… (More)
DOI: 10.1016/j.mam.2017.11.007

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