The PDE4B gene confers sex-specific protection against schizophrenia.

  title={The PDE4B gene confers sex-specific protection against schizophrenia.},
  author={Ben S. Pickard and Philippa A Thomson and Andrea Nikie Christoforou and Kathryn L. Evans and S. W. Morris and David J. Porteous and Douglas H R Blackwood and Walter J. Muir},
  journal={Psychiatric genetics},
  volume={17 3},
BACKGROUND Phosphodiesterase 4B (PDE4B) is a candidate gene for schizophrenia and affective disorders through its disruption by a chromosomal translocation in an individual with schizophrenia, its inhibition by the antidepressant rolipram, and its physical interaction with another key candidate, Disrupted in Schizophrenia (DISC1). OBJECTIVE To determine the contribution made by PDE4B to the population risk of schizophrenia and bipolar disorder by carrying out a case-control association study… CONTINUE READING
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