The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum.

@article{LzrMolnr2008ThePC,
  title={The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum.},
  author={Eszter L{\'a}z{\'a}r-Moln{\'a}r and Attila G{\'a}cser and Gordon J Freeman and Steven C. Almo and Stanley G. Nathenson and Joshua D Nosanchuk},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 7},
  pages={2658-63}
}
The PD-1 costimulatory receptor inhibits T cell receptor signaling upon interacting with its ligands PD-L1 and PD-L2. The PD-1/PD-L pathway is critical in maintaining self-tolerance. In this study, we examined the role of PD-1 in a mouse model of acute infection with Histoplasma capsulatum, a major human pathogenic fungus. In a lethal model of histoplasmosis, all PD-1-deficient mice survived infection, whereas the wild-type mice died with disseminated disease. PD-L expression on macrophages and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…