The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b.

@article{Simpson2005ThePF,
  title={The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b.},
  author={Fiona Simpson and Kelly Lammerts van Bueren and Natalie C. Butterfield and Jennifer S. Bennetts and Josephine Bowles and Christelle Adolphe and Lisa A. Simms and Joanne W Young and M. D. Walsh and Barbara A. Leggett and Lindsay F. Fowles and Carol Wicking},
  journal={Experimental cell research},
  year={2005},
  volume={312 1},
  pages={
          73-85
        }
}
The KIAA0101/p15(PAF)/OEATC-1 protein was initially isolated in a yeast two-hybrid screen for proliferating cell nuclear antigen (PCNA) binding partners, and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF). PCNA is involved in DNA replication and damage repair. Using polyclonal antisera raised against a p15(PAF) fusion protein, we have shown that in a range of mammalian tumor and non-tumor cell lines the endogenous p15(PAF) protein localises to the nucleus and the… CONTINUE READING
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