The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.

@article{Fredericks1995ThePF,
  title={The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.},
  author={William J. Fredericks and Naomi Galili and Sunil Mukhopadhyay and Giuseppe Rovera and Jeannette L. Bennicelli and F. G. Barr and F. Rauscher},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 3},
  pages={
          1522-35
        }
}
Alveolar rhabdomyosarcomas are pediatric solid tumors with a hallmark cytogenetic abnormality: translocation of chromosomes 2 and 13 [t(2;13) (q35;q14)]. The genes on each chromosome involved in this translocation have been identified as the transcription factor-encoding genes PAX3 and FKHR. The NH2-terminal paired box and homeodomain DNA-binding domains of PAX3 are fused in frame to COOH-terminal regions of the chromosome 13-derived FKHR gene, a novel member of the forkhead DNA-binding domain… CONTINUE READING
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