The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival.

@article{Jubin2016ThePF,
  title={The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival.},
  author={Tina Jubin and Ashlesha A Kadam and Meet Jariwala and Shantanu Bhatt and Suresh Sutariya and Amina Rafath Gani and Satyendra Gautam and Rasheedunnisa Begum},
  journal={Cell proliferation},
  year={2016},
  volume={49 4},
  pages={
          421-37
        }
}
PARP family members can be found spread across all domains and continue to be essential molecules from lower to higher eukaryotes. Poly (ADP-ribose) polymerase 1 (PARP-1), newly termed ADP-ribosyltransferase D-type 1 (ARTD1), is a ubiquitously expressed ADP-ribosyltransferase (ART) enzyme involved in key cellular processes such as DNA repair and cell death. This review assesses current developments in PARP-1 biology and activation signals for PARP-1, other than conventional DNA damage… CONTINUE READING
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