The PAR network: redundancy and robustness in a symmetry-breaking system

@article{Motegi2013ThePN,
  title={The PAR network: redundancy and robustness in a symmetry-breaking system},
  author={Fumio Motegi and Geraldine Seydoux},
  journal={Philosophical Transactions of the Royal Society B: Biological Sciences},
  year={2013},
  volume={368}
}
  • F. Motegi, G. Seydoux
  • Published 5 November 2013
  • Biology
  • Philosophical Transactions of the Royal Society B: Biological Sciences
To become polarized, cells must first ‘break symmetry’. Symmetry breaking is the process by which an unpolarized, symmetric cell develops a singularity, often at the cell periphery, that is used to develop a polarity axis. The Caenorhabditis elegans zygote breaks symmetry under the influence of the sperm-donated centrosome, which causes the PAR polarity regulators to sort into distinct anterior and posterior cortical domains. Modelling analyses have shown that cortical flows induced by the… 

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