The PAR network: redundancy and robustness in a symmetry-breaking system

@inproceedings{Motegi2013ThePN,
  title={The PAR network: redundancy and robustness in a symmetry-breaking system},
  author={Fumio Motegi and Geraldine Seydoux},
  booktitle={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2013}
}
To become polarized, cells must first 'break symmetry'. Symmetry breaking is the process by which an unpolarized, symmetric cell develops a singularity, often at the cell periphery, that is used to develop a polarity axis. The Caenorhabditis elegans zygote breaks symmetry under the influence of the sperm-donated centrosome, which causes the PAR polarity regulators to sort into distinct anterior and posterior cortical domains. Modelling analyses have shown that cortical flows induced by the… CONTINUE READING
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