The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos.

@article{Fortin2010ThePA,
  title={The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos.},
  author={Samantha M Fortin and Sara L Marshall and Eva C Jaeger and Pauline E Greene and Lauren K Brady and R Elwyn Isaac and Jennifer C Schrandt and Darren R Brooks and Rebecca Lyczak},
  journal={Developmental biology},
  year={2010},
  volume={344 2},
  pages={992-1000}
}
In the one-cell Caenorhabditis elegans embryo, the anterior-posterior (A-P) axis is established when the sperm donated centrosome contacts the posterior cortex. While this contact appears to be essential for axis polarization, little is known about the mechanisms governing centrosome positioning during this process. pam-1 encodes a puromycin sensitive aminopeptidase that regulates centrosome positioning in the early embryo. Previously we showed that pam-1 mutants fail to polarize the A-P axis… CONTINUE READING

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