The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses.

Abstract

Current influenza treatment relies on a single class of antiviral drugs, the neuraminidase inhibitors (NAIs), raising concern over the potential emergence of resistant variants and necessitating the development of novel drugs. In recent years, investigational inhibitors targeting the endonuclease activity of the influenza acidic polymerase (PA) protein have… (More)
DOI: 10.1128/AAC.02460-16

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@article{Jones2017ThePE, title={The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses.}, author={Jeremy C. Jones and Bindumadhav M. Marathe and Peter Vogel and Rodolfo Gasser and Isabel N{\'a}jera and Elena A Govorkova}, journal={Antimicrobial agents and chemotherapy}, year={2017}, volume={61 5} }