The P53 pathway: what questions remain to be explored?

  title={The P53 pathway: what questions remain to be explored?},
  author={Arnold J. Levine and Wenhao Hu and Zhiwei Feng},
  journal={Cell Death and Differentiation},
The p53 pathway is composed of hundreds of genes and their products that respond to a wide variety of stress signals. These responses to stress include apoptosis, cellular senescence or cell cycle arrest. In addition the p53-regulated genes produce proteins that communicate these stress signals to adjacent cells, prevent and repair damaged DNA and create feedback loops that enhance or attenuate p53 activity and communicate with other signal transduction pathways. Many questions remain to be… CONTINUE READING
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