The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation.

@article{Euser2012ThePE,
  title={The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation.},
  author={Anja S. Euser and Lidia R. Arends and Brittany E. Evans and Kirstin Greaves-Lord and A C Huizink and Ingmar H. A. Franken},
  journal={Neuroscience and biobehavioral reviews},
  year={2012},
  volume={36 1},
  pages={572-603}
}
Endophenotypes are intermediate phenotypes on the putative causal pathway from genotype to phenotype and can aid in discovering the genetic etiology of a disorder. There are currently very few suitable endophenotypes available for substance use disorders (SUD). The amplitude of the P300 event-related brain potential is a possible candidate. The present study determined whether the P300 amplitude fulfils two fundamental criteria for an endophenotype: (1) an association with the disorder (disease… CONTINUE READING

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