The P2Y2 nucleotide receptor is an inhibitor of vascular calcification.

@article{Qian2017ThePN,
  title={The P2Y2 nucleotide receptor is an inhibitor of vascular calcification.},
  author={Shaomin Qian and Jenna N. Regan and Maxwell T Shelton and April Marie Hoggatt and Khalid Sharief Mohammad and Paul B. Herring and Cheikh I. Seye},
  journal={Atherosclerosis},
  year={2017},
  volume={257},
  pages={
          38-46
        }
}
BACKGROUND AND AIMS Mutations in the 5'-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification. However, the role of purinergic receptor signaling in the pathology of intimal calcification is not well understood. In this study, we examined whether extracellular nucleotides acting via P2Y2 receptor (P2Y2R) modulate arterial intimal calcification, a condition highly correlated with cardiovascular morbidity. METHODS… CONTINUE READING
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