The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism.

@article{Raffaghello2006ThePR,
  title={The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism.},
  author={Lizzia Raffaghello and Paola Chiozzi and Simonetta Falzoni and Francesco Di Virgilio and Vito Pistoia},
  journal={Cancer research},
  year={2006},
  volume={66 2},
  pages={907-14}
}
P2X(7) is a receptor for extracellular nucleotides expressed by different normal cell types. P2X(7) triggering may result in stimulation of cell proliferation or induction of apoptosis depending on the level of activation. P2X(7) expression and function in B-cell chronic lymphocytic leukemia has been shown to correlate with disease severity. Here, we have asked the question of whether P2X(7) is expressed and functional in neuroblastoma, a pediatric tumor of neuroectodermal origin. P2X(7) was… CONTINUE READING
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