The P2X7 Receptor in Infection and Inflammation.

@article{Virgilio2017ThePR,
  title={The P2X7 Receptor in Infection and Inflammation.},
  author={Francesco Di Virgilio and Diego Dal Ben and Alba Clara Sarti and Anna Lisa Giuliani and Simonetta Falzoni},
  journal={Immunity},
  year={2017},
  volume={47 1},
  pages={
          15-31
        }
}
Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors named P2 receptors (P2Rs). The P2R most involved in inflammation and immunity is the P2X7 receptor (P2X7R), expressed by virtually all cells of innate and adaptive immunity. P2X7R mediates NLRP3 inflammasome activation, cytokine and chemokine release, T lymphocyte survival and differentiation, transcription factor activation, and cell death… CONTINUE READING

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