The P2X1 ion channel in platelet function.

Following vascular injury, the adenosine nucleotide ATP is released from the dense granules of adhering and activated platelets, as well as from injured endothelial cells and damaged red blood cells. ATP instantaneously interacts with the ion channel P2X(1) in the platelet membrane, through autocrine and paracrine mechanisms, amplifying the initial phase of… CONTINUE READING