The P2 receptors and congenital platelet function defects.

  title={The P2 receptors and congenital platelet function defects.},
  author={Marco Cattaneo},
  journal={Seminars in thrombosis and hemostasis},
  volume={31 2},
Platelets possess three P2 receptors: two (P2Y (1) and P2Y (12)) are receptors for adenosine diphosphate (ADP), and one (P2X1) is a receptor for adenosine triphosphate (ATP). The P2Y (1) receptor, which is coupled to Gq and phospholipase C-beta, is responsible for mobilization of ionized calcium from internal stores and mediates the ADP-induced platelet shape change and initial wave of rapidly reversible aggregation. The other ADP receptor, P2Y (12), is negatively coupled to adenylyl cyclase… CONTINUE READING


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