The P blood group system: biochemical, serological, and clinical aspects.

@article{Spitalnik1995ThePB,
  title={The P blood group system: biochemical, serological, and clinical aspects.},
  author={Patrice F. Spitalnik and S. L. Spitalnik},
  journal={Transfusion medicine reviews},
  year={1995},
  volume={9 2},
  pages={
          110-22
        }
}
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52 Citations
Highly Influential Citations
2
Background Citations
17
Methods Citations
1

52 Citations

Citation Type

Citation Type

Chapter 5 – P blood group system
Studies on the genetic basis of Pk, P and P1 blood group antigen expression
TLDR
No clear-cut correlation was found and two previously proposed P2-specific mutations were detected in homozygous form both in P1 and P2 donors indicating that these mutations are not the sole cause of the P1/P2 status.
P1PK, GLOB, and FORS blood group systems and GLOB collection: biochemical and clinical aspects. Do we understand it all yet?
Blood groups and susceptibility to virus infection: new developments
  • D. Branch
  • Biology, Medicine
    Current opinion in hematology
  • 2010
TLDR
The Pk/Gb3 histo-blood group antigen is the first described cell surface expressed natural resistance factor for prevention of HIV infection.
Molecular basis of the globoside-deficient P(k) blood group phenotype. Identification of four inactivating mutations in the UDP-N-acetylgalactosamine: globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase gene.
TLDR
It is concluded that crucial mutations in the globoside synthase gene cause the P(k) phenotype.
Blood Group Antigens as Receptors for Pathogens
TLDR
Although blood group antigens are critically important in transfusion medicine, questions regarding their physiologic functions in the erythrocyte membrane and on epithelial surfaces remain unanswered (Lublin 1995).
Part 4 – Red Cell Blood Groups
Structural and functional diversity of blood group antigens.
  • J. Cartron, Y. Colin
  • Biology
    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
  • 2001
Genetic heterogeneity at the glycosyltransferase loci underlying the GLOB blood group system and collection *
TLDR
The finding of 13 novel mutations in 14 alleles emphasizes further the genetic heterogeneity at the glycosyltransferase loci underlying the GLOB blood group system and collection.
The human P(k) histo-blood group antigen provides protection against HIV-1 infection.
TLDR
It is concluded that P(k) expression strongly influences susceptibility to HIV-1 infection, which implicates P( k) as a new endogenous cell-surface factor that may provide protection against HIV- 1 infection.
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References

SHOWING 1-10 OF 174 REFERENCES
IMMUNOCHEMICAL OBSERVATIONS ON THE HUMAN BLOOD GROUP P SYSTEM
TLDR
The inhibition results suggest a close structural relationship between the P1 and Pk determinants and indicate that the specificity of anti-Pk sera is less closely delineated than that of anti‐P1.
Human erythrocyte P and Pk blood group antigens: identification as glycosphingolipids.
Isoimmunization by a New Blood Factor in Tumor Cells
TLDR
In the course of preparing a 66-year—old female patient for gastric resection of a tumor later diagnosed as adenocarcinoma, difficulties were encountered in selection of compatible donors and observations suggested the presence of a new hereditary factor which is present in the red blood cells of almost all individuals tested.
Characterization of a murine monoclonal antibody specific for the human P1 blood group antigen.
Urinary tract infections and P blood group antigens.
Presence of P blood group antigens on human platelets.
TLDR
The results of these assays demonstrate that platelets express P blood group antigens in parallel to the donor's RBCs.
The glycosphingolipid composition of the placenta of a blood group P fetus delivered by a blood group Pk1 woman and analysis of the anti-globoside antibodies found in maternal serum.
Serological and immunochemical characterization of anti-PP1Pk (anti-Tja) antibodies in blood group little p individuals. Blood group A type 4 recognition due to internal binding.
Glycoproteins with Gal alpha 4Gal are absent from human erythrocyte membranes, indicating that glycolipids are the sole carriers of blood group P activities.
TLDR
All antigenic determinants of the P blood group family on human red cells are exclusively expressed in glycolipids and are absent from glycoproteins.
Lack of correlation of P blood group phenotype and renal scarring.
TLDR
The results do not support a role of the P1 blood group phenotype in the pathogenesis of renal scarring due to previous febrile urinary tract infection.
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