The Outer Pore and Selectivity Filter of TRPA1

@inproceedings{Christensen2016TheOP,
  title={The Outer Pore and Selectivity Filter of TRPA1},
  author={Adam P. Christensen and Nurunisa Akyuz and David P. Corey},
  booktitle={PloS one},
  year={2016}
}
TRPA1 (transient-receptor-potential-related ion channel with ankyrin domains) is a direct receptor or indirect effector for a wide variety of nociceptive signals, and thus is a compelling target for development of analgesic pharmaceuticals such as channel blockers. Recently, the structure of TRPA1 was reported, providing insights into channel assembly and pore architecture. Here we report whole-cell and single-channel current recordings of wild-type human TRPA1 as well as TRPA1 bearing point… CONTINUE READING
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