The Osteogenic Potential of the Marine‐Derived Multi‐Mineral Formula Aquamin Is Enhanced by the Presence of Vitamin D

@article{Widaa2014TheOP,
  title={The Osteogenic Potential of the Marine‐Derived Multi‐Mineral Formula Aquamin Is Enhanced by the Presence of Vitamin D},
  author={Amro Widaa and Orlaith Brennan and Denise M O'Gorman and Fergal Joseph O'Brien},
  journal={Phytotherapy Research},
  year={2014},
  volume={28}
}
Bone degenerative diseases are on the increase globally and are often problematic to treat. This has led to a demand to identify supplements that aid bone growth and formation. Aquamin is a natural multi‐mineral food supplement, derived from the red algae Lithothamnion species which contains calcium, magnesium and 72 other trace minerals. It has been previously reported to increase bone formation and mineralisation. This study aimed to investigate the 28 day in vitro osteogenic response of… 
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Incorporation of the natural marine multi-mineral dietary supplement Aquamin enhances osteogenesis and improves the mechanical properties of a collagen-based bone graft substitute.
A Natural, Calcium-Rich Marine Multi-mineral Complex Preserves Bone Structure, Composition and Strength in an Ovariectomised Rat Model of Osteoporosis
TLDR
It is shown that in an animal model of osteoporosis, Aquamin is superior to calcium carbonate at slowing down the onset of bone loss.
Bioactive Compounds from Marine Organisms: Potential for Bone Growth and Healing
TLDR
This review describes currently known soluble osteogenic extracts and compounds from marine invertebrates and algae, and assesses their preclinical potential.
Effects of Vitamin D, K1, and K2 Supplementation on Bone Formation byOsteoblasts In Vitro: A Meta-analysis
Bone loss is a major health problem that many aging individuals will face and thus research focusing on enhancing bone formation is of great importance. Cell biology or in vitro studies are…
Comparative characterization study of plant based calcium vs synthetic calcium
Calcium is an essential mineral which supports bone health as well as serves as a major therapeutic intervention that can prevent and delay the incidence of osteoporosis.Multicellular aquatic plants…
Biological evaluation of bone substitute
Aquamin Research: Minerals from Red Algae
TLDR
In an effort to summarize the scientific evidence supporting the claims for this product, this article reviews eight publications identified in PubMed as of November 29, 2013 using the search term “Aquamin” or the company author’s last name “O’Gorman DM”.
Utilisation des algues dans les compléments alimentaires : usages et justifications scientifiques
TLDR
Un travail propose de connaitre plus particulierement le cas des algues, categorie de plantes que l’on recense dans pres de cent references de complements alimentaires vendus en pharmacie.
A Natural Calcium-rich Multi-mineral Complex Preserves Bones Structure, Composition and Strength in an Ovariectomized Rat Model of Osteoporosis

References

SHOWING 1-10 OF 38 REFERENCES
The Marine‐derived, Multi‐mineral formula, Aquamin, Enhances Mineralisation of Osteoblast Cells In Vitro
TLDR
It is reported here that Aquamin promotes increased mineralisation in osteoblast cell culture, suggesting that the nutritional supplement Aquamin plays an important role in promoting bone formation and may be useful in treating bone diseases such as osteoporosis.
Evidence that the marine‐derived multi‐mineral aquamin has anti‐inflammatory effects on cortical glial‐enriched cultures
TLDR
It is reported that Aquamin prevented lipopolysaccharide‐induced secretion of tumor necrosis factor‐alpha and interleukin‐1beta from cortical glia, suggesting that nutritional supplements such as Aquamin may play an important role in impeding the detrimental effects of excessive inflammation in the brain.
A Mineral-Rich Extract from the Red Marine Algae Lithothamnion calcareum Preserves Bone Structure and Function in Female Mice on a Western-Style Diet
TLDR
Female mice on the HFWD had reduced bone mineralization and reduced bone strength relative to female mice on a low-fat chow diet, but in fact, female mice receiving the mineral-rich extract included as a dietary supplement had better bone structure/function than did female mouse on the low- fat chow diets.
Evidence that Marine‐derived, Multi‐mineral, Aquamin Inhibits the NF‐κB Signaling Pathway In Vitro
TLDR
An anti‐inflammatory role for Aquamin is described in inhibiting NF‐κB activation through reducing the phosphorylation and degradation of its upstream inhibitor IκBα.
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TLDR
The mouse system can offer a feasible detection method for assessment of osteogenic activity in the development of functional foods and medicines by noninvasive screening.
A natural seaweed derived mineral supplement (Aquamin F) for knee osteoarthritis: A randomised, placebo controlled pilot study
TLDR
A small preliminary study suggests Aquamin may increase range of motion and walking distances in subjects with OA of the knee and may allow partial withdrawal of NSAIDs over 12 weeks of treatment.
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TLDR
The results indicate that the extracellular calcium level regulates BMPs and type I collagen synthesis in osteoblastic cells.
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TLDR
It is suggested that a multi mineral supplement (Aquamin) may reduce the pain and stiffness of osteoarthritis of the knee over 12 weeks of treatment and warrants further study.
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