The Osmoprotective Function of the NFAT5 Transcription Factor in T Cell Development and Activation1

@article{Trama2002TheOF,
  title={The Osmoprotective Function of the NFAT5 Transcription Factor in T Cell Development and Activation1},
  author={J. Trama and W. Go and S. Ho},
  journal={The Journal of Immunology},
  year={2002},
  volume={169},
  pages={5477 - 5488}
}
The NFAT5/TonEBP transcription factor, a recently identified rel/NF-κB family member, activates transcription of osmocompensatory genes in response to extracellular hyperosmotic stress. However, the function of NFAT5 under isosmotic conditions present in vivo remains unknown. Here we demonstrate that NFAT5 is necessary for optimal T cell development in vivo and allows for optimal cell growth ex vivo under conditions associated with osmotic stress. Transgenic mice expressing an inhibitory form… Expand
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TLDR
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TLDR
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