The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

@article{Ivanov2006TheON,
  title={The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells},
  author={I. I. Ivanov and B. McKenzie and L. Zhou and C. Tadokoro and Alice Lepelley and J. Lafaille and D. Cua and D. Littman},
  journal={Cell},
  year={2006},
  volume={126},
  pages={1121-1133}
}
  • I. I. Ivanov, B. McKenzie, +5 authors D. Littman
  • Published 2006
  • Biology
  • Cell
  • Summary IL-17-producing T lymphocytes have been recently shown to comprise a distinct lineage of proinflammatory T helper cells, termed Th17 cells, that are major contributors to autoimmune disease. We show here that the orphan nuclear receptor RORγt is the key transcription factor that orchestrates the differentiation of this effector cell lineage. RORγt induces transcription of the genes encoding IL-17 and the related cytokine IL-17F in naive CD4 + T helper cells and is required for their… CONTINUE READING

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