The Orphan G Protein–Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons

  title={The Orphan G Protein–Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons},
  author={Amantha Thathiah and Koenraad Frederik Florentina Spittaels and Marcel Hoffmann and Mik Staes and Alan Cohen and Katrien Horr{\'e} and Mieke Vanbrabant and Frea Coun and Veerle Baekelandt and André Delacourte and David F Fischer and Dieter Pollet and Bart de Strooper and Pascal Merchiers},
  pages={946 - 951}
Deposition of the amyloid-β peptide is a pathological hallmark of Alzheimer's disease. A high-throughput functional genomics screen identified G protein–coupled receptor 3 (GPR3), a constitutively active orphan G protein–coupled receptor, as a modulator of amyloid-β production. Overexpression of GPR3 stimulated amyloid-β production, whereas genetic ablation of GPR3 prevented accumulation of the amyloid-β peptide in vitro and in an Alzheimer's disease mouse model. GPR3 expression led to… 
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