The Origins of Mesenchymal Stromal Cell Heterogeneity

  title={The Origins of Mesenchymal Stromal Cell Heterogeneity},
  author={Meirav Pevsner-Fischer and Sarit Levin and Dov Zipori},
  journal={Stem Cell Reviews and Reports},
Cultured mesenchymal stromal cell (MSC) populations are best characterized by the capacity of some cells within this population to differentiate into mesodermal derivatives such as osteoblasts, chondrocytes and adipocytes. However, this progenitor property is not shared by all cells within the MSC population. Furthermore, MSCs exhibit variability in their phenotypes, including proliferation capacity, expression of cell surface markers and ability to secrete cytokines. These facts raise three… CONTINUE READING