The Origins of HLA‐A,B,C Polymorphism

@article{Parham1995TheOO,
  title={The Origins of HLA‐A,B,C Polymorphism},
  author={Peter Parham and Erin J. Adams and Kelly L Arnett},
  journal={Immunological Reviews},
  year={1995},
  volume={143}
}
Polymorphism of HLA-A,B and C genes determines the repertoire of receptor specificities expressed by cytolytic CDS T lymphocytes (CTL) and the response of natural killer (NK) cells. In the performance of these functions HLA-A,B,C heavy chains interact with ^i-microglobulin (/A-m), a multitude of peptides of 810 amino acids, diverse T-cell receptors (TcR), the CD8 co-receptor, class I receptors of NK cells, the TAP peptide transporter, and the chaperonins calnexin and heavy chain binding protein… Expand
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