The Origins of Genome Complexity

@article{Lynch2003TheOO,
  title={The Origins of Genome Complexity},
  author={Michael Lynch and John S. Conery},
  journal={Science},
  year={2003},
  volume={302},
  pages={1401 - 1404}
}
Complete genomic sequences from diverse phylogenetic lineages reveal notable increases in genome complexity from prokaryotes to multicellular eukaryotes. The changes include gradual increases in gene number, resulting from the retention of duplicate genes, and more abrupt increases in the abundance of spliceosomal introns and mobile genetic elements. We argue that many of these modifications emerged passively in response to the long-term population-size reductions that accompanied increases in… Expand

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