The Origins of African Plasmodium vivax; Insights from Mitochondrial Genome Sequencing

  title={The Origins of African Plasmodium vivax; Insights from Mitochondrial Genome Sequencing},
  author={Richard Culleton and Cevayir Coban and Fadile Yildiz Zeyrek and Pedro V L Cravo and Akira Kaneko and Milijaona Randrianarivelojosia and Voahangy Hanitriniaina Andrianaranjaka and Shigeyuki Kano and Anna Farnert and Ana Paula Arez and Paul M Sharp and Richard J Carter and Kazuyuki Tanabe},
  booktitle={PloS one},
Plasmodium vivax, the second most prevalent of the human malaria parasites, is estimated to affect 75 million people annually. It is very rare, however, in west and central Africa, due to the high prevalence of the Duffy negative phenotype in the human population. Due to its rarity in Africa, previous studies on the phylogeny of world-wide P. vivax have suffered from insufficient samples of African parasites. Here we compare the mitochondrial sequence diversity of parasites from Africa with… CONTINUE READING
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Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus

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