The Origin of the Dispute over the Discovery of Heparin

@article{Marcum2000TheOO,
  title={The Origin of the Dispute over the Discovery of Heparin},
  author={James A. Marcum},
  journal={Journal of the History of Medicine and Allied Sciences},
  year={2000},
  volume={55},
  pages={37 - 66}
}
  • J. Marcum
  • Published 2000
  • Medicine
  • Journal of the History of Medicine and Allied Sciences
L'article relate les faits qui ont suivi la decouverte de l'heparine, notamment la dispute pour l'appropriation de la decouverte de cet anticoagulant qui fut a la base de nombreux progres dans le domaine medical et chirurgical. 

Topics from this paper

A tale of two anticoagulants: warfarin and heparin.
This article relays the story of 3 men, Karl Paul Link, who is the discoverer of warfarin, and William Henry Howell and Jay McLean, who are the discoverers of heparin.
The story of the discovery of heparin and warfarin
TLDR
The story of warfarin leads us from a mysterious haemorrhagic disease of cattle to the development of a rat poison which became one of the most commonly prescribed drugs in history.
Skill, drive and luck: the discovery and development of heparin
As the CMAJ celebrates its centenary it is worth remembering that another fixture of the medical landscape will also soon turn 100. Heparin, one of the oldest drugs still in clinical use, remains
A Century of Heparin.
2018 is the centennial of the naming of heparin by Emmett Holt and William Howell and the 102nd anniversary of Jay McLean's discovery of an anticoagulant heparphosphatide at Johns Hopkins. We discuss
The History of Antithrombotic Therapy: The Discovery of Heparin, the Vitamin K Antagonists, and the Utility of Aspirin.
  • R. Handin
  • Medicine
    Hematology/oncology clinics of North America
  • 2016
The administration of intravenous heparin to postoperative patients by Barritt and Jordan reduced the incidence of fatal and nonfatal pulmonary embolism and established heparin as the standard for
One Hundred Years of Heparin
TLDR
Heparin is a highly-sulfated glycosaminoglycan, a fat-soluble anticoagulant in canine liver tissue that was discovered serendipitously in the course of a problem.
Heparin: new life for an old drug.
TLDR
The composition, purification and structure-function relationship of this naturally occurring glycosaminoglycan regarding its classical role as anticoagulant, and its therapeutic potential in, among other, inflammatory and infectious disease, cancer treatment, cystic fibrosis and Alzheimer's disease are dealt with.
Novel oral anticoagulants for prophylaxis and treatment of venous thromboembolism: part I (Factor Xa inhibitors)
  • R. Mehta
  • Medicine
    Expert review of hematology
  • 2010
TLDR
This article reviews oral Factor Xa inhibitors, such as rivaroxaban, apixaban, eribaxaban, edoxaban and YM150 – exploring the outcomes of major clinical trials for prophylaxis and treatment of venous thromboembolism and also briefly outlining their pharmacological properties.
Famous discoveries by medical students
TLDR
The breadth and depth of some of the extraordinary contributions made by gifted and determined medical students undertaking a period of basic scientific or clinical research are explored.
Anticoagulation strategies and difficulties in neonatal and paediatric extracorporeal membrane oxygenation (ECMO)
TLDR
The international ELSO registry data reveals increasing rates of anticoagulation-related complications during neonatal and paediatric ECMO worldwide and the proposed solution to the problem is to match antICOagulation management to the pathophysiological complexity of haemostasis on ECMO.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 57 REFERENCES
The development of heparin in Toronto.
  • J. Marcum
  • Medicine
    Journal of the history of medicine and allied sciences
  • 1997
Les proprietes anticoagulante de l'heparine furent decouvertes a Toronto par McLean (J.) en 1916, puis confirmees par Howell (W.H.) en 1918
Posthumous Award Commemorating the Discovery of Heparin
IN recognition of Jay McLean's major contribution to the discovery of heparin in 1916 as a second-year medical student in collaboration with Professor William H. Howell, a plaque was presented to J...
[Contribution to the study of heparin].
Evidence has been obtained for the presence in heparin of glucosamine-N-sulfate groups (-NH-SO3H) by the elimination of other alternatives and by transformation of heparin into an inactive nitroso
History of drugs for thrombotic disease. Discovery, development, and directions for the future.
TLDR
The discoverers of these diverse agents have provided physicians with a potent armamentarium of antithrombotic drugs but also helped elucidate much basic science and vividly demonstrated the merits of perseverance, independent thought, and adherance to the scientific method.
Heparin in thrombosis and embolism
TLDR
Heparin was discovered by Howell in 1916 and he showed that it increased the coagulation time of blood and fibrin made its appearance, so that, ultimately, the ordinary blood‐clotting processes were added to those of the earlier thrombus.
USE OF HEPARIN IN SUBACUTE BACTERIAL ENDOCARDITIS: A PRELIMINARY REPORT
TLDR
Further studies on both dogs and human beings suffering from subacute endocarditis of the Streptococcus viridans variety revealed that the blood did not lack the ability to destroy the organism in vitro and its inability to do so in vivo was due to the fact that the effective agent in the blood, the white blood cell, was unable to reach the focus of infection.
Preparation of Heparin and Its Use in the First Clinical Cases
TLDR
Tributes are paid to Dr. MlcLean, the discoverer of heparin, and to Professor W. H. Howell and his colleagues, who extended this work and focused the attention on many of the most important prob-lenis in this field.
STUDIES ON THE THROMBOPLASTIC ACTION OF CEPHALIN
A great deal of light has been thrown recently upon the process of coagulation of the blood and the part played by the different blood constituents in this process. All the various theories on the
THE THROMBOPLASTIC ACTION OF CEPHALIN
In 1912 Howell (1) reported the results of a study of the thromboplastic action of the tissues in which he showed that the active substance is a phosphatid having the general properties of cephalin.
Heparin and the formation of white thrombi
TLDR
The results of these experiments show that heparin exerts an effect upon the accumulation of platelets and, therefore, support the conclusions of Murray et al. who found that the frequency of the appearance of mixed thrombi, after mechanical or chemical injury to veins, was appreciably decreased when a solution of purified Heparin was administered for adequate periods before and after the injury had been produced.
...
1
2
3
4
5
...