The Origin Recognition Complex Localizes to Telomere Repeats and Prevents Telomere-Circle Formation

Chromosome ends are maintained by telomere-repeat-binding factors (TRFs) that coordinate DNA end protection with telomere replication. The origin recognition complex (ORC) coordinates bidirectional DNA replication at most chromosomal sites, but it is also known to function in transcriptional silencing, heterochromatin formation, and sister-chromatid… CONTINUE READING