The Organization of Tight Junctions in Epithelia: Implications for Mammary Gland Biology and Breast Tumorigenesis

@article{Itoh2003TheOO,
  title={The Organization of Tight Junctions in Epithelia: Implications for Mammary Gland Biology and Breast Tumorigenesis},
  author={Masahiko Itoh and Mina J. Bissell},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2003},
  volume={8},
  pages={449-462}
}
Tight junctions (TJs), the most apical components of the cell–cell junctional complexes, play a crucial role in the establishment and maintenance of cell polarity within tissues. In secretory glandular tissues, such as the mammary gland, TJs are crucial for separating apical and basolateral domains. TJs also create the variable barrier regulating paracellular movement of molecules through epithelial sheets, thereby maintaining tissue homeostasis. Recent advances reveal that TJs exist as… CONTINUE READING

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