The Orexin-1 Receptor Antagonist SB-334867 Blocks the Effects of Antipsychotics on the Activity of A9 and A10 Dopamine Neurons: Implications for Antipsychotic Therapy

@article{Rasmussen2007TheOR,
  title={The Orexin-1 Receptor Antagonist SB-334867 Blocks the Effects of Antipsychotics on the Activity of A9 and A10 Dopamine Neurons: Implications for Antipsychotic Therapy},
  author={Kurt Rasmussen and Mei-Ann Hsu and Yili Yang},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={786-792}
}
  • Kurt Rasmussen, Mei-Ann Hsu, Yili Yang
  • Published in Neuropsychopharmacology 2007
  • Psychology, Medicine
  • Antipsychotic drugs alter the activity of dopamine neurons in the ventral tegmental area (A10) and substantia nigra pars compacta (A9). As there is a dense projection of orexin neurons from the lateral hypothalamus to A10 dopaminergic neurons, and some antipsychotics have been shown to increase the expression of c-fos in orexin-containing cells in the hypothalamus, we hypothesized that stimulation of orexin receptors plays a role in the effects of antipsychotics on the activity of A9 and A10… CONTINUE READING

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    Citations

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    Reduced plasma orexin-A levels in patients with bipolar disorder

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