The Orbitrap: a new mass spectrometer.

@article{Hu2005TheOA,
  title={The Orbitrap: a new mass spectrometer.},
  author={Qizhi Hu and Robert J. Noll and Hongyan Li and Alexander A. Makarov and Mark Hardman and R. Graham Cooks},
  journal={Journal of mass spectrometry : JMS},
  year={2005},
  volume={40 4},
  pages={
          430-43
        }
}
Research areas such as proteomics and metabolomics are driving the demand for mass spectrometers that have high performance but modest power requirements, size, and cost. This paper describes such an instrument, the Orbitrap, based on a new type of mass analyzer invented by Makarov. The Orbitrap operates by radially trapping ions about a central spindle electrode. An outer barrel-like electrode is coaxial with the inner spindlelike electrode and mass/charge values are measured from the… Expand
Orbitrap mass spectrometry: instrumentation, ion motion and applications.
TLDR
This review begins with a brief account of the set of inventions that led to the orbitrap, followed by a qualitative description of ion capture, ion motion in the trap and modes of detection, and various orbitrap instruments, including the commercially available linear ion trap-orbitrap hybrid mass spectrometers, are discussed. Expand
Fourier Transform-Ion Mobility-Orbitrap Mass Spectrometer: A Next-Generation Instrument for Native Mass Spectrometry.
TLDR
A new instrument configuration for native ion mobility-mass spectrometry (IM-MS) is described, which provides a means to overcome the inherent duty cycle mismatch for drift tube (DT)-IM and Orbitrap mass analysis. Expand
Evolution of Orbitrap Mass Spectrometry Instrumentation.
TLDR
The compelling potential of Orbitrap-based mass spectrometers as (ultra) high-resolution platforms, not only for high-end proteomic applications, but also for routine targeted analysis, is illustrated. Expand
Recent developments in ion-trap mass spectrometry and related technologies
  • F. Brancia
  • Medicine, Chemistry
  • Expert review of proteomics
  • 2006
TLDR
Improvements in instrumental design have led to the linear ion trap, digital ion trap and orbitrap, and Activation methods based on electrons, chemically produced by an anion or from irradiation with an electron beam, have demonstrated their utility in providing complementary sequence information for improving confidence in protein identification. Expand
Fundamentals and Advances of Orbitrap Mass Spectrometry
Analytical chemistry has considerably benefited from the developments in the field of mass spectrometry. The high resolution, mass accuracy, and sensitivity offered by modern mass spectrometers haveExpand
1 Introduction to Mass Spectrometry , a Tutorial
In the past 30 years, mass spectrometry (MS) has undergone a spectacular development, in terms of both its technological innovation and its extent of application. On-line liquid chromatography–massExpand
Development and Evaluation of a Reverse-Entry Ion Source Orbitrap Mass Spectrometer
TLDR
The charge state distributions for ubiquitin and AmtB obtained on the REIS are in agreement with previous studies which suggests that the REis-orbitrap EMR retains native structure in the gas phase. Expand
A Dual Pressure Linear Ion Trap Orbitrap Instrument with Very High Sequencing Speed*
TLDR
A next generation LTQ Orbitrap system termed Velos is described, with significantly increased sensitivity and scan speed, and an improved higher-energy collisional dissociation cell with increased ion extraction capabilities was implemented. Expand
FT-ICR MS optimization for the analysis of intact proteins.
TLDR
It is found that the analysis of large macro-molecules can be significantly improved by the further reduction of pressure in the ion trapping cell, which reduces the high energy ion losses and can enable increased sensitivity and mass measurement accuracy to be realized without compromising resolution. Expand
Mass Analyzers and Mass Spectrometers.
  • Anthony M Haag
  • Materials Science, Medicine
  • Advances in experimental medicine and biology
  • 2016
TLDR
The choice of analyzer is dependant on the properties of the analyte after ionization and the requirements of the experiment being performed, where biomolecules may be of low molecular weight or often take on multiple charges after Ionization. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 95 REFERENCES
Interfacing the orbitrap mass analyzer to an electrospray ion source.
TLDR
This work proves that such a trap could be coupled to a continuous, electrospray, ion source and the development of an rf-only quadrupole for external accumulation of ions and their injection in very short (< 1 micros) ion bunches was developed. Expand
Fourier transform ion cyclotron resonance mass spectrometry: a primer.
TLDR
This review offers an introduction to the principles and generic applications of FT-ICR mass spectrometry, directed to readers with no prior experience with the technique, and lists accurate fundamental constants needed for ultrahigh-precision analysis. Expand
A quadrupole ion trap/time-of-flight mass spectrometer with a parabolic reflectron.
A matrix-assisted laser desorption/ionization-quadrupole ion trap/reflectron time-of-flight (MALDI-QIT/reTOF) mass spectrometer design and its operation in both normal and tandem mass spectrometricExpand
Novel linear quadrupole ion trap/FT mass spectrometer: performance characterization and use in the comparative analysis of histone H3 post-translational modifications.
TLDR
Methodology is described that uses this instrument to compare the post-translational modifications present on histone H3 isolated from asynchronously growing cells and cells arrested in mitosis. Expand
Using accurate mass electrospray ionization-time-of-flight mass spectrometry with in-source collision-induced dissociation to sequence peptide mixtures.
TLDR
A novel approach is presented for simultaneous peptide fragmentation and accurate mass measurement using in-source collision-induced dissociation (CID) on electrospray ionization (ESI)-time-of-flight (TOF) MS. Expand
Tandem mass spectrometry: A primer
Tandem mass spectrometry (MS/MS) employs two stages of mass analysis in order to examine selectively the fragmentation of particular ions in a mixture of ions. The various types of instruments whichExpand
A new linear ion trap mass spectrometer
Characteristics of mass selective axial ion ejection from a linear quadrupole ion trap in the presence of an auxiliary quadrupole field are described. Ion ejection is shown to occur through couplingExpand
Mass analysis at the advent of the 21st century.
TLDR
The demands resulting from current analytical needs are likely to be met to varying degrees but probably not by a single analyzer technology or hybrid instrument, relative to competing approaches. Expand
An interface with a linear quadrupole ion guide for an electrospray-ion trap mass spectrometer system.
TLDR
It is demonstrated that the resolution and sensitivity of the 3D trap can be increased dramatically with ejection of the excess PPG matrix ions, and a 5-fold increase in sensitivity with a 7 times shorter acquisition time was achieved. Expand
Electrostatic axially harmonic orbital trapping: a high-performance technique of mass analysis
  • Makarov
  • Medicine, Chemistry
  • Analytical chemistry
  • 2000
TLDR
This work describes a new type of mass analyzer which employs trapping in an electrostatic field and demonstrates high-mass resolution up to 150,000 for ions produced by laser ablation, along with high-energy acceptance and wide mass range. Expand
...
1
2
3
4
5
...