The Optimal Number of Biopsy Fragments to Establish a Morphologic Diagnosis of Eosinophilic Esophagitis

@article{Nielsen2014TheON,
  title={The Optimal Number of Biopsy Fragments to Establish a Morphologic Diagnosis of Eosinophilic Esophagitis},
  author={J. A. Nielsen and D. Lager and M. Lewin and G. Rend{\'o}n and C. A. Roberts},
  journal={The American Journal of Gastroenterology},
  year={2014},
  volume={109},
  pages={515-520}
}
OBJECTIVES:Eosinophilic esophagitis (EoE) is characterized clinically by dysphagia, chest pain, and food impaction, and morphologically by increased numbers of intraepithelial eosinophils and marked basal hyperplasia of the squamous mucosa. The consensus criteria for a diagnosis of EoE include the presence of ≥15 eosinophils/HPF in biopsies from both proximal and distal esophagus in the absence of other causes of esophageal eosinophilia, and the lack of clinical response to proton pump… Expand
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