The Ontogeny of Cerebral and Cerebellar Nitric Oxide Synthase in the Guinea Pig and Rat

@article{Lizasoain1996TheOO,
  title={The Ontogeny of Cerebral and Cerebellar Nitric Oxide Synthase in the Guinea Pig and Rat},
  author={Ignacio Lizasoain and Carl P. Weiner and Richard Graham Knowles and Salvador Moncada},
  journal={Pediatric Research},
  year={1996},
  volume={39},
  pages={779-783}
}
The appearance of nitric oxide synthase (NOS, EC 1.14.13.39) activity in the brain of fetal and neonatal guinea pigs and rats was studied. In the guinea pig, NOS increased from an almost undetectable level at 0.49 of gestation (31 d), reaching adult levels before birth and peaking at 140% of the adult activity (forebrain) or 250% of the adult activity (cerebellum) in the week after birth. The rise in fetal NOS activity followed the reported rise in the estrogen receptor concentration in the… CONTINUE READING