The Onset of Breathing at Birth Stimulates Pulmonary Vascular Prostacyclin Synthesis

@article{Leffler1984TheOO,
  title={The Onset of Breathing at Birth Stimulates Pulmonary Vascular Prostacyclin Synthesis},
  author={Charles W. Leffler and Jack R Hessler and Robert S. Green},
  journal={Pediatric Research},
  year={1984},
  volume={18},
  pages={938-942}
}
Summary: The purpose of the present study was to determine if pulmonary prostacyclin synthesis was stimulated by spontaneous onset of breathing by unanesthetized fetuses at birth. Cannulae were implanted and flow cuffs placed in fetal lambs and goats (0.93 term). Fetuses were delivered by cesarean section at 0.95 term and began breathing spontaneously. Prostacyclin in blood was determined by radioimmunoassay of its hydrolysis product, 6-ketoprostaglandin F1α using methods that produced the same… CONTINUE READING

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