The Onset of Breathing at Birth Stimulates Pulmonary Vascular Prostacyclin Synthesis

  title={The Onset of Breathing at Birth Stimulates Pulmonary Vascular Prostacyclin Synthesis},
  author={Charles W. Leffler and Jack R Hessler and Robert S. Green},
  journal={Pediatric Research},
Summary: The purpose of the present study was to determine if pulmonary prostacyclin synthesis was stimulated by spontaneous onset of breathing by unanesthetized fetuses at birth. Cannulae were implanted and flow cuffs placed in fetal lambs and goats (0.93 term). Fetuses were delivered by cesarean section at 0.95 term and began breathing spontaneously. Prostacyclin in blood was determined by radioimmunoassay of its hydrolysis product, 6-ketoprostaglandin F1α using methods that produced the same… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 47 extracted citations

Persistent Pulmonary Hypertension of the Newborn : Recent Advances in the Management

Amit Agrawala, Rashmi Agrawalb
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 38 references

[Pulmonary and systemic vascular effects of ATP in man].

Comptes rendus des seances de la Societe de biologie et de ses filiales • 1986

Activation of the branched - chain aketoacid dehydrogenase complex by a broad specificity protein phosphatase

RA Hams, R Paxton, RA Parker
Biochem Pharmacol • 1982

Humoral factors affecting pulmonary blood flow in the fetus and newborn infant

S Cassin
Report of the Eighty-Third Ross • 1982

Neonatal pulmonary vascular prostaglandin production during hypoxia

R Green, CW Lemer
Clin Res • 1982

Pulmonary metabolism of vasoactive substances in normal and asphyxiated births

Ross Conference on Pediatric Research • 1982

Similar Papers

Loading similar papers…