The Ongoing Battle Against Influenza: Drug-resistant influenza viruses: why fitness matters

@article{Kelso2012TheOB,
  title={The Ongoing Battle Against Influenza: Drug-resistant influenza viruses: why fitness matters},
  author={Anne Kelso and Aeron C. Hurt},
  journal={Nature Medicine},
  year={2012},
  volume={18},
  pages={1470-1471}
}
Influenza viruses can spread explosively and cause devastating disease. Of the few drugs we have to reduce the impact of influenza, oseltamivir is the most widely used and stockpiled. However, just over four years ago, A(H1N1) influenza viruses circulating in humans rapidly acquired a mutation that conferred oseltamivir resistance without a loss of viral fitness—their ability to infect, replicate in and be transmitted by the host—in the absence of the drug1,2. This lineage of seasonal H1N1… CONTINUE READING