The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers

@inproceedings{Parato2012TheOP,
  title={The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers},
  author={Kelley A. Parato and Caroline J. Breitbach and Fabrice Le Boeuf and Jiahu Wang and Chris J. Storbeck and Carolina S Ilkow and Jean-Simon Diallo and Theresa Falls and Joseph K. Burns and Vanessa P. Garcia and Femina Kanji and Laura Evgin and Kang Quan Hu and Francois Paradis and Shane Knowles and Tae-Ho Hwang and Barbara C Vanderhyden and Rebecca Ann C Auer and David H. Kirn and John Cameron Bell},
  booktitle={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2012}
}
Oncolytic viruses are generally designed to be cancer selective on the basis of a single genetic mutation. JX-594 is a thymidine kinase (TK) gene-inactivated oncolytic vaccinia virus expressing granulocyte-macrophage colony-stimulating factor (GM-CSF) and lac-Z transgenes that is designed to destroy cancer cells through replication-dependent cell lysis and stimulation of antitumoral immunity. JX-594 has demonstrated a favorable safety profile and reproducible tumor necrosis in a variety of… CONTINUE READING
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