The Omega-3 Polyunsaturated Fatty Acid DHA Induces Simultaneous Apoptosis and Autophagy via Mitochondrial ROS-Mediated Akt-mTOR Signaling in Prostate Cancer Cells Expressing Mutant p53

@inproceedings{Shin2013TheOP,
  title={The Omega-3 Polyunsaturated Fatty Acid DHA Induces Simultaneous Apoptosis and Autophagy via Mitochondrial ROS-Mediated Akt-mTOR Signaling in Prostate Cancer Cells Expressing Mutant p53},
  author={Soyeon Shin and Kaipeng Jing and Soyeon Jeong and Nayeong Kim and Kyoung-Sub Song and Jun-Young Heo and Ji-Hoon Park and Kang-Sik Seo and Jeongsu Han and Jeonghyun Park and Gi-Ryang Kweon and Seung-kiel Park and Tong Wu and Byung-Doo Hwang and Kyu Lim},
  booktitle={BioMed research international},
  year={2013}
}
Docosahexaenoic acid (DHA) induces autophagy-associated apoptotic cell death in wild-type p53 cancer cells via regulation of p53. The present study investigated the effects of DHA on PC3 and DU145 prostate cancer cell lines harboring mutant p53. Results show that, in addition to apoptosis, DHA increased the expression levels of lipidated form LC3B and potently stimulated the autophagic flux, suggesting that DHA induces both autophagy and apoptosis in cancer cells expressing mutant p53. DHA led… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 56 CITATIONS, ESTIMATED 74% COVERAGE

Effect of p 53 gene polymorphism on functions of prostate cancer cells

  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Krill oil extract suppresses the proliferation of colorectal cancer cells through activation of caspase 3/9

Abilasha Gayani Jayathilake, Elif Kadife, Rodney B Luwor, Kulmira Nurgali, Xiao Q Su
  • Nutrition & Metabolism
  • 2019
VIEW 2 EXCERPTS
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2013
2019

CITATION STATISTICS

  • 6 Highly Influenced Citations

  • Averaged 9 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Cancer statistics, 2012

R. Siegel, D.Naishadham, andA. Jemal
  • CA Cancer Journal for Clinicians, vol. 62, no. 1, pp. 10–29, 2012.
  • 2012
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL