The Olive Oil-Based Lipid Clinoleic Blocks Leukocyte Recruitment and Improves Survival during Systemic Inflammation: A Comparative In Vivo Study of Different Parenteral Lipid Emulsions

@article{Buschmann2015TheOO,
  title={The Olive Oil-Based Lipid Clinoleic Blocks Leukocyte Recruitment and Improves Survival during Systemic Inflammation: A Comparative In Vivo Study of Different Parenteral Lipid Emulsions},
  author={Kirsten Buschmann and Johannes Poeschl and Natascha Braach and Hannes Hudalla and Navina Kuss and David Frommhold},
  journal={Mediators of Inflammation},
  year={2015},
  volume={2015}
}
Although fish oil-based and olive oil-based lipid emulsions have been shown to exert anti-inflammatory functions, the immunomodulating properties of lipids are still controversial. Therefore, we investigated the anti-inflammatory effect of three different parenterally administered lipid emulsions in vivo: olive oil-based Clinoleic, fish oil-based Smoflipid, and soybean oil-based Lipofundin. We observed leukocyte recruitment in inflamed murine cremaster muscle using intravital microscopy and… 
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References

SHOWING 1-10 OF 81 REFERENCES
Olive oil-based lipid emulsion's neutral effects on neutrophil functions and leukocyte-endothelial cell interactions.
TLDR
LCT-MUFA showed lower in vitro and in vivo impact on neutrophil function compared with LCT and LCT-MCT, and Lipopolysaccharide (LPS)-induced increase in leukocyte rolling flux, adhesion, and emigration was inhibited by LCT, but unaffected in LCT -MUFA-treated rats.
Fatty acids, lipid emulsions and the immune and inflammatory systems.
TLDR
The inclusion of fish oil in combination with one or more other oils in the parenteral regimen administered to patients following major gastrointestinal surgery reduces the post-surgery rise in inflammatory markers and the fall in cell-mediated immune markers.
Comparison of 5 intravenous lipid emulsions and their effects on hepatic steatosis in a murine model.
TLDR
The fish oil-based lipid emulsion Omegaven prevented hepatic steatosis and EFAD in this murine model and may be efficacious in preventing PNALD and should be explored in the development of novel lipid emulsions.
Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation.
TLDR
It is concluded that during acute inflammation and sepsis, PC is a fast acting and effective therapeutic approach to block leukocyte recruitment and improve survival.
MECHANISMS OF INCREASED SURVIVAL AFTER LIPOPOLYSACCHARIDE-INDUCED ENDOTOXIC SHOCK IN MICE CONSUMING OLIVE OIL-ENRICHED DIET
TLDR
Data indicate that intake of OO may have a beneficial role, reducing the magnitude of the inflammatory process triggered by endotoxic shock through modulation of LB formation and of the production of inflammatory mediators.
Medium-chain Triglyceride Supplementation Exacerbates Peritonitis-Induced Septic Shock in Rats: Role on Cell Membrane Remodeling
TLDR
The mixture of MCTs/LCTs significantly increased cardiac and vascular nitric oxide and superoxide anion production, phosphorylated I&kgr;B, and cyclooxygenase 2 expression compared with the lipid emulsion containing only LCTs, inducing deleterious effects with increased inflammation and cell activation.
Ο‰-3 vs. Ο‰-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation
TLDR
Lipid-based parenteral nutrition in septic patients may exert profound influence on sequelae and status of immunocompetence and inflammation, and Ο‰-6 lipid emulsions differentially influence the plasma free fatty acid profile with impact on neutrophil functions.
Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis.
TLDR
Use of lipid infusions might allow us to combine intravenous alimentation with differential impact on inflammatory events and immunologic functions in patients with sepsis.
Olive oil is more potent than fish oil to reduce septic pulmonary dysfunctions in rats
TLDR
The lung may be protected by an enteral immunonutrition containing long chain triglycerides such as olive oil, being more potent than fish oil to reduce septic pulmonary dysfunction.
The addition of medium-chain triglycerides to a purified fish oil-based diet alters inflammatory profiles in mice.
TLDR
Inclusion of MCT in lipid emulsions given with PN formulations may be of use in therapeutic interventions for disease states resulting from chronic inflammation, and may pose potential for optimized PN formulation.
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